Pharmaceutical Intermediate Sodium Acetate Anhydrous
CAS NO.: 127-09-3
Molecular Formula: CH3COONa
Molecular Weight: 82.03
Character: white crystal powder; specific gravity is 1.528 and melting point is 324℃.
Usage: It is a kind of chemical raw material and is widely used in dye, pharmaceutical, chemical reagent fields, sewagement and etc.
Package: 25kg plastic woven bag or 1000kg Ton-bag
Storage: It should be stored in a dry and ventilative warehouse, kept away from heat and moisture during transportation, unloaded with care so as to avoid damage. Furthermore, it must be stored separately from poisonous substances.
- Product Description
Pharmaceutical Intermediate Sodium Acetate Anhydrous — High-Purity Buffering Agent for Pharma Synthesis
Pharmaceutical Intermediate Sodium Acetate Anhydrous (CAS 127-09-3) is a white crystalline powder with a molecular weight of 82.03 g/mol, a melting point of 324°C and a specific gravity of 1.528. It complies with the high quality requirements of pharmaceutical synthesis. Purity ≥99% Moisture ≤0.3% Impurities Heavy metals ≤0.0005% Chlorides ≤0.005% Produced by Shanxi Zhaoyi Chemical Co., Ltd. — Founded in 1988, the product has 150,000 tonnes annual capacity and enables reliable and large scale supply with a 5-7 working day lead time and 24 hour delivery for stock orders.
Technical Specifications
Parameter | Specification |
Content (CH3COONa) | ≥99.0% |
Molecular Formula | CH3COONa |
Molecular Weight | 82.03 |
CAS Number | 127-09-3 |
Appearance | White crystal powder |
Specific Gravity | 1.528 |
Melting Point | 324℃ |
pH (5% solution) | 7.5-9.2 |
Clarity Test | Qualified |
Water Insoluble | ≤0.01% |
Chloride (Cl) | ≤0.002% |
Sulfate (SO4) | ≤0.01% |
Phosphate (PO4) | ≤0.001% |
Magnesium (Mg) | ≤0.002% |
Calcium (Ca) | ≤0.05% |
Ferrum (Fe) | ≤0.0005% |
Heavy Metal (as Pb) | ≤0.002% |
How It Performs in Pharmaceutical Synthesis
This product is a sodium acetate anhydrous pharma intermediate and provides significant synthesis contributions when utilised as such.
pH Control: It keeps the reaction in a mildly alkaline environment (pH 7.5-9.0) for the whole reaction process, which creates circumstances conducive to increased yield and purity of pharmaceutical intermediates.
Acid-Buffering Function: It buffers the acids formed during the synthesis processes. This speeds the response ahead and decreases side effects greatly.
Yield enhancement In the synthesis of cephalosporin intermediates, the addition of sodium acetate anhydrous (1.2% of the total weight of the reaction system) improved the reaction yield by 12%–18%. The usual addition range varies from 0.5%-2.0% depending on the synthesis procedure. Small scale testing is suggested to discover the best ratio for your own particular process. Technical help is offered during this process.
Lower Purification Costs: Low impurity levels indicate less downstream contamination problems – particularly very tight chloride and heavy metal levels. This alleviates the downstream purification processes and enhances the overall efficiency of the manufacturing process.
Key Product Characteristics
This is a dry grade and physically different from sodium acetate trihydrate. It has a low moisture content, tightly managed to ≤0.3%, thus will not introduce undesired water into watertight processes. This makes it especially useful for synthesis phases where moisture control is crucial.
The anhydrous version also has a larger density of active acetate ions by weight. You obtain more reactive material per kilogram than the trihydrate version, which immediately enhances logistical efficiency and cost-per-reaction efficacy.
It hydrolyzes and is soluble in water at 119 g/100 ml (0°C), and is moderately soluble in ethanol, allowing easy incorporation into a variety of chemical systems. The product was equally dispersed and may interact uniformly with additional reagents for the synthesis.
Application Areas
Pharmaceutical Intermediate Sodium Acetate Anhydrous is widely used across multiple synthesis fields. Its compatibility with common synthetic raw materials and absence of harmful impurity introduction make it a reliable reagent across these applications.
· Cephalosporin intermediate synthesis — buffering and yield optimization
· General API (Active Pharmaceutical Ingredient) manufacturing — pH control and acid neutralization
· Chemical reagent production — high-purity buffer component
· Dye chemistry — reaction modifier and buffering agent
· Wastewater treatment in pharma facilities — process chemical
For injectable-grade or dialysis-grade pharmaceutical processes, bacterial endotoxin levels should be verified. Endotoxin control (typically < 3.9 EU/mg) is a critical safety parameter at this application level.
Pharmaceutical Intermediate Sodium Acetate Anhydrous vs Other Products
Feature | Our Anhydrous Grade | Standard Industrial Grade | Trihydrate Form |
Purity (CH3COONa) | ≥99.0% | 98.0-98.5% | Lower effective content |
Heavy Metals (Pb) | ≤0.002% | ≤0.005% | ≤0.005% |
Iron (Fe) | ≤0.0005% | ≤0.002% | ≤0.002% |
Water Content | <0.1% | 0.5-2.0% | ~39% (crystal water) |
Active Ion Density | Highest | Medium | Lowest per kg |
Water-Sensitive Compatibility | Excellent | Fair | Poor |
Pharmaceutical Certification | ISO/KOSHER/HALAL | Limited | Varies |
Price per Active Unit | Competitive | Lower absolute price | Highest logistics cost |
Certifications & Compliance
Shanxi Zhaoyi Chemical Co., Ltd. maintains a full suite of international management system certifications. These support your quality, safety, and regulatory compliance requirements.
· ISO 9001 — Quality Management System
· ISO 14001 — Environmental Management System
· ISO 45001 — Occupational Health and Safety Management System
· Kosher Certification
· Halal Certification (applicable grades)
We are a leading provider of Anhydrous Sodium Acetate USP EP and can provide full compliance paperwork including COA, MSDS and multilingual conformity papers. Allows for third-party testing. We accept on-site plant audits from both local and foreign clients.
Storage & Packaging
Anhydrous sodium acetate is very hygroscopic. Proper storage is required to maintain its purity and to prevent moisture uptake which will degrade its anhydrous specification.
Storage: Store in a dry well aired facility. Transport: keep in a cool, dry place Handle with care. Do not damage package. Keep clear from dangerous substances.
Available packaging:
· 25 kg plastic woven bags
· 1,000 kg ton bags (jumbo bags)
Customized packaging formats and OEM labeling are available upon request.
FAQ
Q: Does this product fulfil the demanding standards for pharmaceutical intermediate synthesis in terms of purity?
A: Yes. Purity , >99.0% (dry basis) Chloride , <0.005% Heavy metals , <0.0005% These standards are developed expressly to suit pharmaceutical intermediate synthesis requirements and include third-party testing.
Q: Will impurities in the product affect subsequent drug synthesis or final product quality?
A: The impurity levels are quite tight at all important parameters. Low chloride, heavy metals and iron concentration decreases contamination risk and downstream purifying costs. This helps to maintain the integrity of your synthesis process.
Q: What is the recommended addition ratio for cephalosporin intermediate synthesis?
A: The general addition range is 0.5%–2.0% of the total reaction system weight. For cephalosporin intermediates, 1.2% has been shown to improve yield by 12%–18%. Customers are advised to conduct small-scale trials, and our technical team can provide full support.
Q: Will there be adverse reactions when this product is mixed with other synthesis raw materials?
A: The product shows good compatibility with common synthesis raw materials. It does not introduce harmful impurities, and its anhydrous nature means it won't interfere with water-sensitive reaction systems.
Q: What is the supply capacity for bulk orders?
A: With an annual production capacity of 150,000 tons of acetate products across a 27,000 m² facility, large and continuous orders are well supported. Standard lead time is 5–7 working days, with 24-hour delivery available for stock orders.
Q: What are the storage requirements, and what is the shelf life?
A: Store in a cool, dry, and well-ventilated area, away from heat, moisture, and incompatible substances. Due to its hygroscopic nature, keep packaging sealed until use. When stored correctly, the product maintains its specification throughout the standard shelf life period. Contact us for specific shelf life documentation.
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Contact Us
Ready to source high-purity sodium acetate anhydrous for your Pharmaceutical Intermediate Sodium Acetate Anhydrous? Contact our team at sxzy@sxzhaoyi.com — response within 2 hours.
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